Isabella has undergone six rounds of chemotherapy, which have significantly shrunk the tumour. What do they love about it?
But for Julie Neville, wife of Everton captain and former England ace Phil, the cash sum was a target. She set about raising that amount for a children's hospital after her daughter was born with a devastating disability. Isabella, now six, was born three months prematurely and spent weeks fighting for life in a special care unit.
And when she was just 18 months old her parents were told that she had cerebral palsy and may never walk. Julie and Phil, who also have an eightyear-old son, Harvey, were still coming to terms with the news when Julie agreed to fundraise for the new Royal Manchester Children's Hospital. Then I got a call from Sarah Naysmith.
She was working to set up a charity to raise funds for the new children's hospital and wanted us to be patrons. She was 20 miles away. If this hospital with its accommodation blocks had been open then, I'd never have had to leave her. I don't have a nanny as I want to do everything for them myself.
Then after school we have extra activities. She wears splints on her legs to straighten them and sometimes needs a walking frame for support, but she has been walking since she was two and a half.
He comes to every single hospital appointment. So we ask Harvey to show her what to do and she will follow. He is there for her all the time, so protective - he picks her up if she falls and carries her plate to the table because she can't do it on her own.
It is a credit to her that she has got so many people to take notice. Isabella never views herself as one of the 'sick children'.
She might have a disability, but she doesn't moan and just gets on with it. First she got the support of local radio DJs and Coronation Street stars.
Regional meals from the local auberge can also be delivered. A freezer full of French home made dishes to use as and when you need Vegetarian and gluten free also available. Francesca was incredible and made us cookies and muffins on our first night and dropped off a strawberry cake for us the second night.
The Browns agreed to hold a reception at No10 for the hospital appeal and its supporters to boost its profile. Julie and Phil also fronted three of the Mini Manchester Runs.
Last year, to start one of the fundraising races, little Isabella ran alongside Olympic champion Usain Bolt. But she wasn't about to sit down and put her feet up. Now she has launched another appeal to raise funds for specialist equipment, research into children's illnesses and to create a more child-friendly hospital environment.
Schools must register for the event before April 16 to be in with the chance of winning a visit from Phil. We are delighted they have agreed to continue to support us.
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